A10.22 Response to MTX Plus Prednisone in Camera II Using a Multi-Biomarker Disease Activity (Vectra™DA) TEST and DAS28-ESR

Abstract

<b>Introduction:</b> Aspiration pneumonia (AP) is a dominant form of community-acquired, hospital-acquired and nursing and healthcare-associated pneumonia, and a leading cause of death among ageing populations.However, the risk factors for fatal outcome in AP with postural drainage (PD) have not been fully evaluated. <b>Aims and objectives:</b> The purpose of the present study was to determine the risk factors for fatal outcome in AP with PD. <b>Methods:</b> Retrospective study from 04/2014 to 03/2015 of patiens with clinically and radiologically confirmed AP and were performed PD in our hospital. We conducted a case-control study using 33 cases with dead and 95 age- and sex-frequency-matched controls with alive. <b>Result:</b> A total of 128 AP cases with PD were identified. There were 73(57%) male patients, the mean age was 83±9 years. In the univariateanalysis, daily oxygen therapy was a significant risk factor for fatal outcome in AP with PD (odds ratio[OR], 2.81, 95% confidence interval [CI], 1.17-6.78, P&lt;0.05), WBC of at the end of antibiotic treatment (OR, 4.04,95% CI, 2.03-8.05, P&lt;0.01) and CRP (OR, 3.61, 95% CI, 1.58-8.22, P&lt;0.01). In the multiple logistic regression analysis, the risk factors for fatal outcome associated with AP with PD after adjustment for age,sex, bmi and smoking status, were daily oxygen therapy (OR, 6.23, 95% CI, 2.55-15.2, P&lt;0.01), WBC of at the end of antibiotic treatment (OR, 5.02, 95% CI, 2.30-10.9, P&lt;0.01) and CRP (OR, 3.71,95% CI, 1.56-8.82, P&lt;0.01). <b>Conclusion:</b> The risk factors for fatal outcomes in AP with PD were clearly daily oxygen therapy, WBC and CRP of the end of antibiotic therapy. These results could help improve clinical management for AP with PD.