A0996 Downregulated serum 14, 15-EET is associated with abdominal aortic calcification in patients with primary aldosteronism

Abstract

Objectives: To investigate the association between 14, 15-epoxyeicosatrienoic acid (14, 15-EET) and abdominal aortic calcification (AAC) in patients with Patients with primary aldosteronism (PA). Methods: 14, 15-dihydroxyeicosatrienoic acid (14, 15-DHET), the inactive metabolite from 14, 15-EET, was estimated to reflect serum 14, 15-EET levels. AAC was assessed by computed tomographic scanning. Results: Compared with matched controls, the AAC prevalence was almost one-fold higher in patients with PA [27 (39.1%) vs. 14 (20.3%), P = 0.023], accompanied by significantly higher serum 14, 15-DHET levels [(7.18 ± 4.98) vs. (3.50 ± 2.07) ng/mL, P < 0.001]. Plasma aldosterone concentration was positively associated with 14, 15-DHET (β = 0.444, P < 0.001). Multivariable logistic analysis revealed that lower 14, 15-DHET was an independent risk factor for AAC in PA (odds ratio [95% confidence interval], 1.371 [1.145–1.640], P < 0.001), especially in young patients with mild hypertension and normal body mass index. Conclusion: In conclusion, PA patients exhibited more severe AAC, accompanied by higher serum 14, 15-DHET levels. On the other hand, decreased 14, 15-EET was significantly associated with AAC prevalence in PA patients, especially in those at low cardiovascular risk.