A060 Māori and Pacific Patients With Non-Ischaemic Cardiomyopathy, Undergoing Cardiac Magnetic Resonance Imaging Have Worse Clinical Outcomes than European Patients

Abstract

Cardiac Magnetic Resonance (CMR) imaging is increasingly utilised to assess the aetiology and severity of cardiomyopathies. Non-ischaemic cardiomyopathy (NICM) is a heterogeneous condition, with varying clinical and demographic factors influencing outcome. This study assesses differences in clinical outcomes in European compared with Māori and Pacific NICM patients undergoing CMR in South Auckland. CMR reports from Counties Manukau District Health Board region (2005 – 2019) were analysed from an ANZACS-QI linked CMR database. 536 patients with a diagnosis of NICM were identified and linked ethnicity data recorded. 498 patients were grouped according to European (n = 231) vs Māori and Pacific ethnicity (n = 267). Clinical, biochemical, imaging and demographic data was collected from electronic medical records. The primary end point was combined all cause mortality and readmission rate for decompensated heart failure. Māori and Pacific patients were younger (52.3 +/-11.6 vs 57.2 +/- 14.6 years, p<0.001), had higher Body Mass Index (36.7 kg/m2 vs 29.5 kg/m2 , p<0.001), and weight (105.3kg vs 87.4kg, p<0.001). CMR markers of left ventricular (LV) volumes (p=0.95), LV ejection fraction (p=0.14), and presence of myocardial fibrosis (p=0.13) were similar between the two groups. Implantable Cardiac Defibrillator, and Cardiac Resynchronisation Therapy implantation rates were similar (p=0.58). The primary combined outcome of readmission for decompensated heart failure and all cause mortality was significantly higher in Māori and Pacific patients (96 vs 48, p<0.001). Māori and Pacific patients with NICM have worse clinical outcomes than European patients, despite similar disease severity on CMR.