Abstract
Abstract[Zn6(L)4(DMF)2(H2O)4](1,4-Dioxane)2(DMF)10(H2O)4 (1, L = 4,4′,4″-(benzene-1,3,5-triyltris(oxy))tribenzoate), the metal-organic cage, was produced via Zn(NO3)2·6H2O reacting with the H3L ligand in the mixed solvent of DMF and water. The heterogeneous catalytic activities of the complex 1 for the aldehydes cyanidation under the conditions of free solvent were studied, which indicates that the removal of coordination solvents could greatly improve the catalytic activities. Furthermore, the inhibitory effect of the compound against the ovarian cancer cells was assessed. The mi-RNA16 relative expression level was measured after exposure to the compound with real-time reverse transcription-polymerase chain reaction. The invasion and migration of cells after compound treatment were also detected by the transwell method.
Highlights
Micro RNA is a group of endogenous noncoding small molecular RNAs of about 21–23 nucleotides in length that are widely found in eukaryotes [1]
Metalorganic polyhedron (MOP) have been extensively utilized for many organic reactions as catalytic centers
Li and his colleagues have reported the ringopening of styrene oxide promoted via the MOP [15]; Wang and co-workers have applied an In(III)–MOP as the heterogeneous catalyst in Strecker reaction of aminonitriles and CO2 cycloaddition [16]
Summary
Micro RNA (micro RNA, mi RNA) is a group of endogenous noncoding small molecular RNAs of about 21–23 nucleotides in length that are widely found in eukaryotes [1]. They are involved in the regulation of gene posttranscriptional levels and have a very significant function in the apoptosis and differentiation of cells. Metalorganic polyhedron (MOP) is a kind of discrete container molecules and assembled via functional organic ligands and metal ions by the coordination bonds. MOPs have been extensively utilized for many organic reactions as catalytic centers. The results for the invasion and migration of cancer cells suggested that the compound reveals an outstanding inhibitory effect against cancer cells
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