Abstract
Similar to the Drosophila homeobox gene sine oculis, several of the vertebrate homologues ( Six genes) are expressed during eye formation and differentiation. In addition, most of these vertebrate genes show expression in mesodermal derivatives in adults and/or earlier stages of development. We have identified a zebrafish ( Danio rerio) gene, six8, which shows the greatest similarity to murine Six4. The deduced proteins of these two genes have an overall sequence identity of 41%, while the homeodomains and Six domains are highly conserved, 90% and 81%, respectively. The spatiotemporal expression pattern of six8 was analyzed by RT-PCR and in situ hybridization. Transcripts were detected in a wide range of embryonic stages and in adults. Notably, the strongest expression was observed in head mesoderm of late gastrula and early neurula stages.
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