Abstract
A zebrafish model for nevus regeneration
Highlights
Dear Editor, Nevi are senescent and benign tumors of melanocytes, some of which can progress to melanoma (GraySchopfer et al, 2007)
BRAFV600E nevi develop in the young adult fish, and once formed remain static, and do not continue to grow for the remainder of the life of the fish
Even in BRAFV600E animals that are deficient for p53, only some fish-nevi progress to melanoma (Patton et al, 2005), suggesting that the constraints on fish-nevus growth are robust and that multiple cellular changes are required to promote transformation to melanoma
Summary
Citation for published version: Richardson, J, Zeng, Z, Ceol, C, Mione, M, Jackson, I & Patton, EE 2011, 'A zebrafish model for nevus regeneration', Pigment Cell and Melanoma Research, vol 24, no. 2, pp. 378-381. https://doi.org/10.1111/j.1755-148X.2011.00839.x General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights.
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