A year in the life of SARS-CoV-2 Mpro: molecular modeling and analysis of clinically observed Mpro variants from the first year of the COVID-19 pandemic

Elizabeth M Diessner,Gemma R Takahashi,Thomas J Cross,Carter T Butts,Rachel W Martin

doi:10.1016/j.bpj.2021.11.2498

A year in the life of SARS-CoV-2 Mpro: molecular modeling and analysis of clinically observed Mpro variants from the first year of the COVID-19 pandemic

Elizabeth M Diessner, Gemma R Takahashi + Show 3 more

Open Access

https://doi.org/10.1016/j.bpj.2021.11.2498

Copy DOI

Journal: Biophysical journal	Publication Date: Feb 1, 2022
License type: publisher-specific-oa

Affiliation: University of California, Irvine, University of California, Los Angeles

#Roles In Viral Replication #Main Protease + Show 8 more

Abstract
Full-Text PDF
Similar Papers

Abstract

The SARS-CoV-2 main protease, Mpro, is a highly selective protein responsible for separating the polyprotein produced by the viral RNA into its functional units, which subsequently play critical roles in viral replication. Mpro is highly conserved among sarbecoviruses and essential for viral reproduction, making it an important target for genomic and biophysical study. Within the first year of the COVID-19 pandemic, numerous genomic variants have emerged, many of which have been detected from clinical samples.

Full Text