Abstract
Objective. Cancer stem cells have been identified in several human cancers including solid tumors, such as breast tumors, and head and neck squamous cell carcinomas. The search for stem cells in ovarian cancer is hampered by the lack of an efficient assay system. The identification of human cancer stem cells requires a xenograft model of tumor formation in order to assay for tumorigenic potential. We established a xenograft model of ovarian cancer from primary human epithelial ovarian carcinomas using immunodeficient mice that can be used to detect human ovarian cancer stem cells.
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