Abstract
ABSTRACTWe report here the genome sequence of a hepatitis E virus (HEV) strain from a chronically infected immunodeficient patient. Full-length sequence analysis revealed a distinct HEV strain, of a tentative new subgenotype, clustering with viruses from rabbits. It is a World Health Organization reference strain for validation of nucleic acid testing.
Highlights
First identified in people, certain strains of hepatitis E virus (HEV) have been found to be widespread in animals such as domestic pigs and wild boar
An international reference panel (IRP, code number 8578/13) of HEV strains has been prepared on behalf of the World Health Organization (WHO) for validating nucleic acid tests and standardizing assays [13, 14]
A human HEV strain related to viruses found in rabbits is included in the WHO IRP and was obtained from a stool sample from a 47-year-old French male who presented with elevated levels of alanine aminotransferase while undergoing routine surveillance 9 years after receiving a liver transplant as a result of hepatitis B virus-related cirrhosis
Summary
First identified in people, certain strains of hepatitis E virus (HEV) have been found to be widespread in animals such as domestic pigs and wild boar. An international reference panel (IRP, code number 8578/13) of HEV strains has been prepared on behalf of the World Health Organization (WHO) for validating nucleic acid tests and standardizing assays [13, 14]. A human HEV strain related to viruses found in rabbits is included in the WHO IRP and was obtained from a stool sample from a 47-year-old French male who presented with elevated levels of alanine aminotransferase while undergoing routine surveillance 9 years after receiving a liver transplant as a result of hepatitis B virus-related cirrhosis.
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