A wearable insulin delivery system based on a piezoelectric micropump

Abstract

A piezoelectric micropump-based wearable insulin delivery system for artificial pancreas health is proposed. The system consists of a piezoelectric micropump, electrical control, and other mechanical modules. The piezoelectric micropump adopts a dual-chamber series structure with asynchronous drive and is made of a biocompatible polymer. The proposed insulin delivery system has a simple form, low failure rate, and adaptability to common voltage working conditions. The experimental results show that at 36 V, 200 Hz, the output flow and pressure of the system are 9.6 ml/min and 17.3 kPa, respectively. Meanwhile, the flow rate accuracy reaches 2 × 10 −4 ml, and the output flow is well linear with the pulses. Animal experiments show that the proposed wearable insulin delivery system has a significant hypoglycemic effect on large-eared white rabbits (artificial hyperglycemia), verifying its feasibility in practical applications. A piezoelectric micropump-based wearable insulin delivery system for artificial pancreas health is proposed. The system consists of a piezoelectric micropump, electrical control, and other mechanical modules. A systematic performance test and preliminary animal experiments were conducted to verify its practical feasibility. At 36 V, 200 Hz, the system output backpressure reaches 17.3 kPa, and the output volume has a good linear relationship with the pulse. The minimum resolution volume of the device is 3 × 10 −4 ml, which provides a stable base rate and accuracy. Animal experiments have verified that the device has a significant effect on the control of blood glucose levels in large-eared white rabbits. This provides a reference for the application of piezo pumps in the biological and pharmaceutical fields. • A system for insulin delivery. • Piezoelectric drive sources. • It is able to maintain blood glucose balance in the body. • Low cost and simple structure with application potential.