Abstract
Abstract Background An early event in the pathogenesis of vitiligo may be the chronic oxidative stress via elevated hydrogen peroxide due to decreased blood catalase. There are controversial reports on association of vitiligo and +22348C→T polymorphism. Methods We examined this polymorphism and blood catalase in Hungarian vitiligo patients (n: 78) and controls (n: 201). Genomic DNA was extracted from leukocytes and a PCR/SSCP method was used for genetic examination. Results Blood catalase activity, genotype and allele frequencies did not change in Hungarian vitiligo patients. The mutant CT and TT genotypes yielded decreased (p 0.0813), contrary to the significant (p < 0.05) increase of mutant CT genotype and T allele frequencies in US/Canada and in UK. Conclusions Our results based on blood catalase determinations and genetic examination of +22348C→T polymorphism sugg...
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