A WAY TO INCREASE EFFECTIVENESS OF PARACETAMOL DRUG THROUGH TRANSDERMAL PATCH

Abstract

Millio ns of people around the world suffers from the fever, effective treatment is essential by formulating Transdermal patch . Paracetamol IP traditionally considered as a NSAID, is an effe ctive analgesic and antipyretic fully sold without prescription . The conv entional formulations containing high dose as well as required to take the medication frequently so increase the risk factor associated with drug . T he prese nt study is an attempt to develop suitable ma trix type patch of Paracetamol using blends of Xanthan Gum and HPMC K 4 M with polyethylene glycol ( PEG - 400 ) as a plasticizer . To get better effect permeation enhancers such as Linseed oil and oleic acid was also incorporated and their optimum concentration was determined . P repared formulations were evaluated fo r compatibility, drug content , moisture loss and absorption, thickness , weight variation, adhesion , folding endurance etc . In vitro permeation study was performed by using Franz diffusion cell . Formulations were found to be uniform in physicochemical param eter with a fewer variations and there was no significant interaction between drug and polymer used . F ormulation of HPMC K 4 M along with Linseed oil showed faster release of drug from develo ped formulations . Based on the o bservation, No burst effect but HP MC K 4 M are better for faster release with linseed oil and xanthan gum for prolonged release for the development of patch . Stability studies indicated the formulations were remained stable both physically and chemically . All developed formulations showed de sired properties of an ideal TDDS and followed zero order rate profile . Thus, the study achieved target s by reduction in frequency of administration and systemic toxicity .