Abstract
To explore the grey matter volume (GMV) changes in neuromyelitis optica (NMO) patients using a voxel-based morphometry method. Whole brain structural images were acquired in 16 NMO patients and 16 gender-and age-matched healthy controls. Comparison of GMV between the two groups was analyzed by VBM8 toolbox of statistical parametric mapping 8. Compared with the controls, NMO patients showed decreased GMV in the frontal lobe, parietal lobe, temporal lobe, occipital lobe, limbic lobe, optic tract, caudate nucleus, thalamus, and cerebellum (all P < 0.005). Regional atrophy of grey matter is found in NMO patients. Voxel-based morphometry can reveal brain volume changes sensitively.
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