Abstract
Abstract This paper describes a hybrid silicon/plastic chip which is used to analyze DNA samples without the need of fluorescence or surface functionalization. The viscosity and density of the solutions to be tested are measured using a vibrating silicon beam immersed in the fluid. The sensitivity of the chip with respect to DNA concentration and length is analyzed, yielding a limit of detection of 0.5 μg/μl. We show that the sensitivity of the chip is statistically significant for PCR end-point detection. State-of-the-art on-chip detection methods of DNA solutions need optical devices or specially designed reactions. With the viscometric method proposed in this paper, these drawbacks are avoided.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
