Abstract
In the course of attempts to infect Syrian hamsters (Cricetus auratus) 2 to 4 months old, with influenza A, virus strain W. S.,1 another filterable agent capable of producing a fatal pneumonia in these animals was found. One hamster was inoculated intranasally with mouse-passage influenzal virus (W.S.) and developed slight nasal symptoms. This animal was sacrificed after 8 days and suspensions of lung and turbinate were passed to a second hamster which had large plum-colored pneumonic areas in its lungs when killed at 6 days. Subsequently suspensions of lung and turbinate have been carried through 17 serial intranasal passages in hamsters with the production of pneumonia in each passage except the first and third. The suspensions at each hamster-passage when inoculated intranasally into mice produced a pneumonia which was usually fatal within 6 to 9 days. Attempts to produce a similar pneumonia in hamsters with several other mouse-passage strains of influenzal virus were unsuccessful. We were also unable ...
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