Abstract
A clinical study of 45 patients and a virological survey of 34 patients with acute lymphoblastic leukemia have been undertaken to detail the characteristics of occurrence of interstitial pneumoniae (IP) under maintenance chemotherapy. Our study confirms the link between IP and treatment with MTX but does not support the hypothesis of an allergic reaction to the drug. The virological study has failed to detect one type of viral agent associated with IP but have shown important modifications of humoral immunity against viruses.
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