Year-end Sale % OFF 
Abstract
Vector-borne pathogens influence host characteristics relevant to host–vector contact, increasing pathogen transmission and survival. Previously, we demonstrated that infection with Turnip mosaic virus, a member of one of the largest families of plant-infecting viruses, increases vector attraction and reproduction on infected hosts. These changes were due to a single viral protein, NIa-Pro. Here we show that NIa-Pro responds to the presence of the aphid vector during infection by relocalizing to the vacuole. Remarkably, vacuolar localization is required for NIa-Pro’s ability to enhance aphid reproduction on host plants, vacuole localization disappears when aphids are removed, and this phenomenon occurs for another potyvirus, Potato virus Y, suggesting a conserved role for the protein in vector–host interactions. Taken together, these results suggest that potyviruses dynamically respond to the presence of their vectors, promoting insect performance and transmission only when needed.
Highlights
A viral protease relocalizes in the presence of the vector to promote vector performance Aurélie Bak
We examined the impact of another potyvirus, Potato virus Y (PVY), and expression of its Nuclear inclusion protein a protease (NIa-Pro) in host plants on aphid vector performance
We show that NIa-Pro from Turnip mosaic virus (TuMV) relocalizes to the vacuole in the presence of insect vectors on infected hosts (Figs 1c,2,3a,b and 5d–f)
Summary
A viral protease relocalizes in the presence of the vector to promote vector performance Aurélie Bak. We demonstrated that infection with Turnip mosaic virus, a member of one of the largest families of plant-infecting viruses, increases vector attraction and reproduction on infected hosts These changes were due to a single viral protein, NIa-Pro. Here we show that NIa-Pro responds to the presence of the aphid vector during infection by relocalizing to the vacuole. Several studies have shown that viruses can suppress plant defences and vectors feeding on virus-infected plants often possess greater fitness than those residing on healthy plants (for review, see refs 5,7–10) These findings suggest that viruses may facilitate their own transmission by modulating host characteristics. This new concept in virology has been called ‘perceptive viral behaviour’ and relies on the fact that viruses respond directly or via the host to potential vectors[11]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
