A Very Rare Relaps Type in Multiple Myeloma: Leptomenıngeal and Cranial Involvement

Abstract

Multiple myeloma is a hematological malignancy that develops as a result of clonal proliferation of plasma cells and progresses with remissions and relapses. It is clinically characterized by many symptoms and signs such as osteolytic bone lesions, hypercalcemia, renal dysfunction, hypergammaglobulinemia and anemia. However, involvement of the central nervous system, especially the leptomeningeal/cranial region, is a rare and prognostically important form of relapse of the disease. This case report discusses this rare clinical presentation, diagnostic approach, and treatment strategies of extramedullary involvement of multiple myeloma.