Abstract

AbstractA flexible synthetic method is presented, which allows all the key isoflavones (daidzein, genistein, glycitein, formononetin and biochanin A) to be prepared in 13C‐labelled form via the same route, involving the thallium(III)‐mediated oxidative rearrangement of a key chalcone intermediate. This method results in the incorporation of 13C atoms at the 2, 3 and 4 positions of the isoflavone skeleton. We also report the first syntheses of 13C‐labelled versions of the daidzein metabolites, equol and ODMA. Copyright © 2009 John Wiley & Sons, Ltd.

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