Abstract
Suzuki coupling of 17-iodoandrosta-5,16-dien-3β-ol ( 1) and 17-iodoandrosta-4,16-dien-3-one ( 2) with nine heteroaryl boronic acids (mainly 2- or 3-furanyl, thienyl, benzofuranyl and benzothienyl boronic acid derivatives) were carried out under normal Suzuki condition (Pd(PPh 3) 4, 2 M Na 2CO 3 and MeOH), generally yielded C 17-heteroaryl steroids in moderate (10–60%) yields, but furanyl-2- and 5-chlorothienyl-2-boronic acid did not give any coupling product.
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