A versatile Bi2S3/MnO2 based nano-theranostic agent for triple-modal imaging guided photothermal/photodynamic synergistic therapy

Abstract

Versatile nano-theranostic agents are highly desirable for the precision nanomedicine of tumors in recent years. In this work, a multifunctional diagnostic and therapeutic agent Bi 2 S 3 -MnO 2 @BSA-Ce6 (BMBC) was successfully prepared by a combination strategy of facile chemical coupling and biomineralization under mild conditions. These BMBC nanoparticles with an average diameter of 17.6 ± 4.6 nm exhibited favorable physiological stability and negligible toxicity. This agent expressed outstanding performance of photothermal conversion (η = 45.8%) under 808 nm laser radiation and generation of 1 O 2 under 650 nm laser irradiation. Due to the strong X-ray attenuation performance of element Bi and the highly effective magnetic moment of Mn 2+ , this agent exhibited favorable performance of X-ray computed tomography (CT) imaging (35.60 HU•mL•mg −1 ) and magnetic resonance (MR) imaging (r 1 = 5.22 mM −1 •s −1 ) in vitro. Furthermore, most of the HeLa cells treated with BMBC NPs were dead in the MTT and Calcein-AM/PI staining experiments, demonstrating the excellent effect of intracellular synergistic therapy. Overall, this theranostic agent could serve as a promising nano-platform for photothermal/photodynamic synergistic therapy of tumors under the guidance of infrared thermal (IRT)/MR/CT imaging. A versatile nano-theranostic agent Bi 2 S 3 -MnO 2 @BSA-Ce6 (BMBC) was successfully constructed and demonstrated its excellent performance of IRT/MR/CT imaging and synergistic PTT/PDT of tumor cells in vivo .