Abstract
Fluoroketones are very important class of compounds due to their high prevalence in pharmaceuticals and their expediency as synthons and building blocks for the synthesis of other therapeutically important molecules. Here we present an efficient environment-friendly straightforward synthetic method for an array of α-fluoroketones, alcohols, and ethers, starting from ubiquitous aryl and alkyl-substituted olefins. This method with broad substrate and product scope, mild and eco-friendly reaction condition, and high yield, provides an efficient and greener alternative to reported syntheses to date. The robustness and generality of the method have been demonstrated through easy scaling up to gram scale and smooth fluorination of several commercial drugs, food additives, and natural products containing both alkyl and aryl-substituted olefins.
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