Abstract
The vesicle trafficking system has long been known to influence signal transduction through its role in biogenesis and degradation of membrane receptors (1). There are also well known examples of vesicle-associated regulatory proteins, such as Ire1 and SREBP, that control responses closely tied to vesicle properties or function (2, 3). But a new paradigm is emerging, as illustrated by a study in this issue of PNAS (4), in which vesicle-associated signal transduction (VAST) may not be related to trafficking of a transmembrane receptor. Rather, vesicles serve as staging areas for regulatory proteins, facilitating interactions that ultimately lead to activation or effector interaction (Fig. 1).
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