Abstract
Purpose. To assess safety and effectiveness of calibrated cyclodialysis ab interno involving implantation of a non-absorbable collagen implant in the suprauveal space in decreasing IOP in glaucoma patients.Methods. Forty-three patients (43 eyes; 16 male and 27 females; average age — 70.4 ± 10.0 years) were included in this pilot study. A 6 mm long and 2.0 mm wide cyclodialysis cleft was created ab interno in one of the lower quadrants of the eye using a specially designed spatula followed by insertion of a strip of implant in the cleft. In 19 eyes (44.3 %) the procedure was performed as standalone procedure and in 24 eyes (55.7 %) along with cataract surgery. Outcome measures were IOP change, use of hypotensive medication(s), complications, and need for a second surgery. Decrease in IOP by >20 % and IOP between 6 and 21 mmHg without hypotensive medication(s) constituted complete success; similar changes in IOP with medication(s) constituted partial success. Need for second surgery constituted failure.Results. At 6 months, baseline IOP decreased from 20.6 ± 7.4 mmHg to 12.9 ± 4.9 mmHg (a decrease by 37.4 %; р < 0.001) and hypotensive medication use reduced from 2.6 ± 0.8 to 1.0 ± 1.1 (a reduction by 57.7 %; р < 0.001). Complete success was achieved in 19 eyes (44.2 %), partial in — 15 eyes (34.9 %). Nine eyes had unsuccessful outcomes (20.9 %); among these, seven eyes (78 %) had severe glaucoma and five eyes (55 %) had undergone previously glaucoma surgeries. Hemorrhaging at the cleft site was the most common intraoperative complication — 18 eyes (41.9 %). Postoperative complications included hyphema, which was completely resorbed within one week.Conclusion. Calibrated cyclodialysis ab interno procedure involving implantation of a non-absorbable collagen implant in the suprauveal is safe and easy to perform. It effectively decreases IOP in patients with moderate glaucoma but is less effective in patients with severe glaucoma and in patients with previously failed glaucoma surgeries. Complications were found to be minimal.
Highlights
Open-angle glaucoma (OAG) is a multifactorial surgical disease
Previous surgical methods in management of glaucoma focused on creating an artificial pathway for Aqueous humor (AH) outflow
Demographic data of the patients and preoperative characteristics of the eyes are presented in table 1
Summary
Open-angle glaucoma (OAG) is a multifactorial surgical disease. Increased intraocular pressure (IOP) is the only fac‐ tor that can be affected by medication, laser or by surgery. Aqueous humor (AH) flows from anterior chamber (AC) through the trabecular pathway and the uveoscleral pathway. Both generally play an equal role in AH outflow [1], though there is evidence of the uveoscleral pathway carrying up to 60 % of the AH outflow in young people [2]. Trabeculectomy effectively decreases IOP for a substantial period but is accompanied by a number of serious complications such as hypotonia, hypo‐ tonic maculopathy, a shallow AC, choroidal effusion, hyphema, bleb leakage, and endophthalmitis [3, 4]. A non-penetrating surgery for glaucoma, is safer and risks fewer complications, but it has short-term hypotensive effect [5]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
