Abstract
A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of bromhexine hydrochloride from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD 0.9999) between 50% to 250% of 0.100 mg of drug substance weight. The percentage recovery of bromhexine hydrochloride in the optimized method was between 99.38 to 99.76%. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.
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