Abstract
A commercial, particular and strong Ion Chromatography method was developed for the quantitative determination of metabisulfite content in Cetrizine Ambroxol syrup. The method was developed using Ion pac AS11HC Column, 250 X 4.6mm X 5.0 m column with mobile phase containing 18mM sodium hydroxide in water. The eluted compounds were monitored using conductivity detector. The developed method was validated as per ICH guidelines with respect to limit of detection(LOD), limit of quantification(LOQ), exactness, reproducibility, ruggedness and robustness. The LOD, LOQ values of metabisulfite were 0.3PPM and 1.0PPM respectively.
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