Abstract
Captopril and telmisartan are widely used anti-hypertensive drugs, and their fixed dose combination is under phase IV trials. In the present study, spectrophotometry and RP-HPLC methods were successfully developed and validated per standard regulations. In UV spectrophotometry method concentrations of captopril and telmisartan in a synthetic mixture prepared in the laboratory were determined using the simultaneous equation method. The linearity was found 8 to 40 μg/mL for captopril and 5 to 25 μg/mL for telmisartan. The R2 (Coefficient of Correlation) value was found to be 0.999 for both drugs. The %assays of the conc. of captopril and telmisartan in synthetic mixture were found in an acceptable range. In the RP-HPLC method %assay was found to be 100.05 and 100.16% with %RSD value of 0.34 and 0.58 for captopril and telmisartan, respectively. The proposed UV and RP-HPLC method simultaneous estimation of captopril and telmisartan has potential application for qualitative identification as well as quantitative determination.
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