Abstract
Depression, a debilitating mental condition with an increasing impact on quality of life, does not always respond well to conventional treatments, which often have side effects that hinder adherence. In this context, phytotherapeutics like Valeriana officinalis and Passiflora incarnata have emerged as promising therapeutic alternatives. This study aimed to review the effectiveness of these phytotherapeutics in treating depression and anxiety. The methodology involved a systematic literature review of 16 articles published between 2014 and 2024, following PRISMA guidelines. Results indicated that both phytotherapeutics significantly reduced depressive and anxiety symptoms, with fewer adverse effects compared to conventional medications. Valeriana officinalis and Passiflora incarnata were observed to modulate the GABA system, promoting symptom relief. However, inconsistent bioactive compound standardization and preparation variability are limitations for clinical application. It is concluded that, while promising, these phytotherapeutics require further research to ensure consistent efficacy and safety.
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