Abstract
3-Sulfenylated indoles as a significant heterocyclic scaffold have garnered enormous interest and utility in the past several decades due to significant biological and pharmaceutical activities, including anti-HIV, anti-obesity and anti-cancer activity. To date, several methods have been developed for the synthesis of 3-sulfenylated indoles using distinct sulfenylating agents. In this review, the recent developments in the metal free synthesis of 3-sulfenylated indoles moieties are covered, which show insight into both the large distinct reactions condition as well as mechanism.
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