Abstract
This article is a tribute and homage to Gerard Chaouat who invited me to contribute this article. My years in France have remained very memorable to me. Reviewed briefly is the vaccine that was made against human chorionic gonadotropin (hCG) to prevent unwanted pregnancy in sexually active women. It has now been developed as a genetically engineered recombinant vaccine and passed onto industry for its production under good manufacturing practices (GMP) conditions for confirmatory trials. The trials have received the approval of the Drugs Controller General of India. The trials have started but have been interrupted by the coronavirus disease 2019 (COVID-19) pandemic. This vaccine is likely to have another highly beneficial application in the treatment of cancers expressing ectopically hCG.
Highlights
Human chorionic gonadotropin is not made normally by a woman and its appearance in urine or blood is taken as an indication of the on-set of pregnancy
Β-human chorionic gonadotropin (hCG) was linked non-covalently to α-subunit of ovine luteinizing hormone (LH)
We obtained the approval of the Review Committee of Genetic Manipulations (RCGM) for our recombinant vaccine after extensive toxicology studies
Summary
A unique vaccine for birth control and treatment of advanced stage cancers secreting ectopically human chorionic gonadotropin. Cite this article: Talwar GP, Gupta JC, Puruswani S, Vyas HK, Nand KN, Pal P, et al A unique vaccine for birth control and treatment of advanced stage cancers secreting ectopically human chorionic gonadotropin.
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