Abstract
Spontaneous regression of cancer is a rare, but well documented, phenomenon. We present a unique case of an 82 year old Chinese male who experienced spontaneous regression of histologically-verified metastatic type II papillary renal cell carcinoma in the absence of intervening systemic therapy or surgery. This is the first reported case of spontaneous regression of papillary renal cell carcinoma. The mechanism of spontaneous regression remains unknown, and represents a challenge for existing oncology paradigms.
Highlights
We present a unique case of an 82 year old Chinese male who experienced spontaneous regression of histologicallyverified metastatic type II papillary renal cell carcinoma in the absence of intervening systemic therapy or surgery
While spontaneous regression of clear cell Renal cell carcinoma (RCC) is recognized as a rare phenomenon, spontaneous regression of papillary RCC has not been previously reported
Our institutional database of RCC has a series of 80 patients with papillary RCC over approximately 20 years, none of whom exhibited spontaneous regression
Summary
Renal cell carcinoma (RCC) accounts for 3% of all new cancer cases worldwide with a rising incidence [1]. The first reported case of spontaneous regression of metastatic RCC was published in 1928 [2]. Almost all documented cases of spontaneous regression of RCC are reported to occur in the metastasis rather than the primary lesion. We present a cytologically verified case of lung metastasis following relapse from papillary RCC, which regressed spontaneously over twelve months without therapy. Over the 12 months, imaging revealed spontaneous regression of the lesion (Figure 2B). He remains free of progressive disease 24 months after relapse. 6 years following surgery, CT scanning revealed a single solid pulmonary lesion in the left lower lobe of the lung (Figure 2A) with no other sites of disease.
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