A unique approach to the synthesis of a dengue vaccine and the novel tetrasaccharide that results

Abstract

An approach to the development of a dengue vaccine by synthesizing the hexasaccharide epitope on the viral surface is examined. The stereochemical and structural challenges include the synthesis of a β-mannoside bond. Synthesis of this bond is approached via a trisaccharide analogue portion of the epitope. A novel tetrasaccharide with a mannose–mannose anomeric linkage results in the course of the synthetic attempts.