Abstract
AbstractA Unified, Microwave assisted, Pd‐catalyzed regioselective ortho‐monohalogenation of 3‐phenylquinoxalin‐2(1H)‐one derivatives has been disclosed using readily available N‐halosuccinimides (NXS). The nitrogen atom of quinoxalin‐2(1H)‐one facilitated as an effective directing group and helped in achieving regioselective mono halogenation at ortho‐position of 3‐phenyl ring of 3‐phenylquinoxalin‐2(1H)‐ones. Under mild reaction condition, a wide diversity of mono halogenated products were obtained with wide substrate scope and high functional group tolerance in good yields. Post‐functionalization of the synthesized molecules has been demonstrated.
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