Abstract
Replication restart from collapsed replication forks can be mutagenic. Mizuno et al. studied replication restart in fission yeast. They found that even when replication restart occurs correctly, if the replication fork encounters a palindromic sequence within the first few kilobases, then the replication machinery occasionally makes a U-turn, generating rearranged daughter chromosomes with absent or multiple centromeres. Such a mechanism might contribute to chromosomal rearrangements and copy number alterations in cancer.
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