Abstract
Context: As an alternative approach, administration of phytotherapeutic agents in management of benign prostate hyperplasia (BPH), is rapidly growing each day. Different authors have indicated effectiveness of Viola odorata L. (Violaceae), Echium amoenum Fisch. & C.A.Mey. (Boraginaceae) and Physalis alkekengi L. (Solanaceae) in treatment of BPH. However, none have reported the beneficial outcomes of the mixture yet. Objective: This study evaluates the therapeutical effects of V. odorata, E. amoenum and P. alkekengi mixture on symptomatic BPH patients. Materials and methods: Eighty six symptomatic BPH patients with International Prostate Symptom Score (IPSS) of more than 13 and prostate volume of more than 30 cm3 were randomly allocated to receive a two-week course of placebo (control group) or 1 mL of mixed hydro-alcoholic solution of P. alkekengi, E. amoenum and V. odorata extracts (1.5, 1 and 1.5% respectively) (treatment group). Results: IPSS score of incomplete urination (42.3 ± 2.04%), frequency of urination (20.08 ± 1.02%), intermittency (40.78 ± 2.16%), urgency (60.91 ± 3.14%), weak stream (50.58 ± 2.14%), straining (55.67 ± 2.53%) and nocturia (40.14 ± 1.89%) in treatment group were significantly decreased after treatment compare to placebo receiving group. Furthermore, the prostate volume (16.92 ± 0.89%) and extant urine volume (28.12 ± 1.36%) also significantly decreased in treatment group compared to control group. No significant side effects or abnormalities in biochemical tests and urinalysis were observed throughout the study. Discussion and conclusions: Based on results, mentioned mixture is safe and effective in improving life quality of patients suffering from BPH.
Highlights
Benign prostatic hyperplasia (BPH) is considered as the most prevalent urologic disorder in elderly men with prevalence rate of more than 70% at 60 years old age and 90% older than 70 years
No statistically significant differences were observed between groups regarding the mean prostate volume, urine flow rate and extant urine volume
Except the Urgency, International Prostate Symptom Score (IPSS) score of all mentioned abnormalities in treatment group was significantly decreased after treatment compared to placebo receiving group
Summary
Benign prostatic hyperplasia (BPH) is considered as the most prevalent urologic disorder in elderly men with prevalence rate of more than 70% at 60 years old age and 90% older than 70 years. It is mostly diagnosed by stromal and glandular cells hyperproliferation around periurethral areas and transition zones of the prostate gland (Untergasser et al 2005; Chughtai et al 2011; Bostanci et al 2013). It is essential to identify and initiate effective treatment strategies in order to overcome these complicated situations in BPH patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
