A two-locus model of selection in autotetraploids: Chromosomal gametic disequilibrium and selection for an adaptive epistatic gene combination.

Abstract

In this paper, we present a two-locus model of selection for an autotetraploid population. We also investigate a measure of disequilibrium that occurs between homologous chromosomes in the diploid gametes of autotetraploids, namely chromosomal gametic disequilibrium. We apply the model and measure of disequilibrium to compare how an adaptive epistatic gene combination is inherited and selected for in an autotetraploid versus diploid population. Autotetraploids are expected to have higher genomic mutation and recombination rates relative to diploids, due to a greater ploidy level. These two processes can work in opposition in terms of selection for adaptive epistatic gene combinations. While a higher genomic mutation rate can generate the alleles that confer an epistatic combination more quickly, a higher recombination rate is expected to break the combination down more quickly. We show that chromosomal gametic disequilibrium in autotetraploids can potentially compensate for less linkage disequilibrium in autotetraploids. We also explore how double reduction affects the inheritance of and selection for an epistatic gene combination. Over all, our analysis provides theoretical evidence that adaptive epistatic combinations can be selected for more efficiently in autotetraploids versus diploids. This may provide insight into empirical work that finds epistasis has a role in causing population differentiation between autotetraploid plant populations.