A two-fluid model for hematocrit distribution in microvascular networks.

Abstract

A new theoretical network model for evaluating discharge hematocrits, explicitly based on plasma skimming at branches, is introduced. The particular network geometry chosen simulates bat wing microvasculature. Blood in vessels is approximated to be a two fluid with red cell suspension as the core and a plasma layer surrounding it. The plasma layer width depends on hematocrit, which leads to nonlinear hydrodynamic equations solved by iteration. Discharge hematocrit distributions are calculated by a computer for five generations of vessels. Dispersion of hematocrit values was found to be correlated to plasma skimming at branches. Contrary to previous suggestions, plasma skimming did not result in lowered mean hematocrit towards the capillaries. Network structure was found to be an important factor affecting the hematocrits. Mean discharge hematocrit remained steady against changes in vessel dimensions, capillary resistances, red cell concentration in plasma layer, and shape of the separation surface defining the streamlines entering the side branch. This high stable mean hematocrit is based on symmetry of the model network. Enhanced asymmetry tended to lower the hematocrit.