Abstract
A two herbs formula has been successfully used as a cardiovascular supplement (tonic) to maintain a healthy vascular endothelial state in four groups of patients presenting with different symptom manifestations: coronary obstruction; hypertension; menopausal cardiovascular instability; and peripheral arterial disease. In parallel with the four clinical trials carried out separately in over ten years, laboratory platform studies to find out the mechanisms of action of the herbal formula have been carried out. The bioactivity tests demonstrated the general efficacy of the formula as being anti-inflammatory and anti-oxidative; while in addition, specific influences on vascular relaxation, cardiac protection, endothelial stability and blood lipid cholesterol adjustments were demonstrated.
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