Abstract
Hypochlorous acid (HClO), a highly reactiveoxygen species, has important effects on human health. High selectivity and sensitivity remain challenges of fluorescent probes for detection of ClO- with a large Stokes shift. This work designed and synthesized a novel phenothiazine-based fluorescent probe TF which can detect ClO- by colorimetric and fluorescent dual signals. TF displayed turn-on fluorescence effect toward ClO- with high selectivity (≥ 28-folds) and sensitivity (LOD = 0.472μM), fast response time (< 1min) and large Stokes shift (150nm) in PBS (pH = 7.4, 40% DMSO). Meanwhile, TF can visualize ClO- on the mung bean sprouts model and apply as testing strips for portable and rapid detecting ClO- by the naked eyes. A phenothiazine-based fluorescent probe with large Stokes shift was synthesized and its responding rapidly ability to detect ClO- was studied.
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