A tuberculosis model with three infected classes

Abstract

The dynamics of tuberculosis within a population cannot be adequately represented by a single infectious class. Therefore, this study develops a compartmental model encompassing latent, active, and drug-resistant populations to better capture tuberculosis dynamics in a community. Model analysis reveals that the disease-free equilibrium point is locally asymptotically stable when the basic reproduction number is below one. Moreover, the use of a suitable Lyapunov function demonstrates global asymptotic stability of the disease-free equilibrium point. An endemic equilibrium emerges when the basic reproduction number exceeds one. Sensitivity analysis is conducted for each parameter associated with the basic reproduction number, and optimal control analysis is employed to assess the impact of various control strategies on disease containment. Numerical simulations are conducted to supplement theoretical findings, illustrating the practical implications of the proposed control strategies.