A triple-chamber parenteral nutrition solution was associated with improved protein intake in very low birthweight infants.

Abstract

We evaluated the nutrient intakes of very low birthweight (VLBW) infants weighing less than 1500g and tested the hypothesis that using a triple-chamber parenteral nutrition (PN) solution, containing lipids, glucose and amino acids, would improve protein intake. This retrospective cohort study comprised 953 VLBW infants born in 2005-2013 at a gestational age of less than 32+0/7weeks and admitted to the neonatal care unit at Helsinki Children's Hospital, Finland. The infants were divided into four groups according their birth year and PN regime. Nutrient intakes were obtained from computerised medication administration records. In 2012-2013, when a triple-chamber PN solution was used, infants were more likely to reach the target parenteral protein intake of 3.5g/kg/d, and reach it 3-7days earlier, compared with infants who received individual PN or standard two-in-one PN solutions in 2005-2011. In addition, infants in the triple-chamber group had the highest median energy intake (90kcal/kg/d) during the first week. They also had higher median protein intakes in weeks one, two and three (3.1, 3.4 and 3.7g/kg/d) than infants born in 2005-2011 (P<.05). Using a triple-chamber PN solution was associated with improved protein intake, and the protein target was more likely to be achieved.