Abstract
The feasibility of a one pot approach for conducting mutually orthogonal thiol-Michael addition, copper catalyzed azide-alkyne and inverse electron demand Diels-Alder click chemistry on a tri-functional substrate was demonstrated.
Highlights
The feasibility of a one pot approach for conducting mutually orthogonal thiol-Michael addition, copper catalyzed azide–alkyne and inverse electron demand Diels–Alder click chemistry on a trifunctional substrate was demonstrated
Material and polymer chemists have rapidly picked up this type of chemistry and adapted it to match their needs in life sciences, polymer science and materials science.[1]
These adaptions did not fulfil the well-established criteria for click chemistry,[2] the aim – joining two different molecules in an efficient way – has been achieved
Summary
The feasibility of a one pot approach for conducting mutually orthogonal thiol-Michael addition, copper catalyzed azide–alkyne and inverse electron demand Diels–Alder click chemistry on a trifunctional substrate was demonstrated. The 1H-NMR spectra of the individual “click” reactions (labelled A, B and C) were evaluated according to the method of Collins et al treating the remaining functional groups as additives.[26] The signals of H7b, H8 and/or H11 were used, as appropriate, for referencing.
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