Abstract
Thirteen trials of SA-97 were carried out on 10 children with chronic asthma. The trials varied from 3 to 45 weeks in duration and the children were on a variety of maintenance therapies which were maintained constant throughout the control and trial period of the drug. The effect of the treatment was assessed by the use of objective measurements of ventilatory function before and after the use of an Adrenalin aerosol. In 10 trials there was an increase in the indirect MBC test during the period of SA-97 therapy of 10 per cent or more above the value during the control period. There was deterioration of this order in one subject. Responsiveness to Adrenalin aerosol was unaffected by SA-97. The effects of SA-97 and Adrenalin aerosol appeared to be additive rather than synergistic.
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