Abstract
Many kinds of venomous principles modulate physiological responses of mammalian signal transduction systems, on which they act selectively as enhancers, inhibitors or some other kind of effectors. These toxins have become useful tools for physiological research. We have characterized paralyzing toxins from the venom of spiders, scorpions, insects, jellyfishes and sea anemones in the subtropical region including the Ryukyu Islands. Venom profiles are screened by MALDI‐TOF fingerprinting analysis prior to purification of the venomous components, then marked target toxins of small molecular mass (1000–5000) are characterized directly by means of mass spectrometric techniques such as Frit‐FAB MS/MS, PSD/CID‐TOF MS, Capil. ‐HPLC/Q‐TOF MS/MS etc. The proteinous toxins of jellyfish or sea anemone are characterized by RT‐PCR technique by the information of the cleaved peptides after the protein was hydrolyzed by appropriate peptidase and the sequence of the cleaved peptide was determined by conventional methods. ...
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