Abstract
The hair follicle (HF) growth cycle is a complex, multistep biological process, for which dysfunction affects hair-related diseases in humans and wool production in animals. In this study, a treatment combination of 10 ng/mL insulin-like growth factor-1 (IGF-1) and 20 ng/mL epidermal growth factor (EGF) significantly increased the elongation length of hair shafts for cultured HFs. The combined treatment of IGF-1 and EGF enhanced the proliferation of HFs and promoted HF growth and development in vitro. In vivo, the combined treatment of IGF-1 and EGF was subcutaneously injected into the dorsal skin in HF synchronized rabbits. The IGF-1 and EGF combination promoted the transition of the hair cycle from telogen to anagen and stimulated the growth of hair shafts. This IGF-1 and EGF combination maintained the structure of the HF and enhanced the cell proliferation of outer root sheaths and the dermal papilla within rabbit skin. The combined treatment of IGF-1 and EGF regulated HF-related genes, including LEF1, CCND1 and WNT2, suggesting that IGF-1 and EGF play a positive role in HF growth and development. Utilization of the combined IGF-1 and EGF treatment may assist with hair and wool production and HF related diseases in mammals.
Highlights
The hair follicle (HF) is complex skin accessory organ, which has a unique structure and plays important roles in growth and development in mammals [1]
We considered the role of insulin-like growth factor-1 (IGF-1) and epidermal growth factor (EGF) in HF growth and development in Angora rabbits
2 ng IGF-1 and 4 ng EGF were dissolved in saline solution, 200 μL of the mixed solution was subcutaneously injected into the dorsal skins of HF synchronized Angora rabbits
Summary
The hair follicle (HF) is complex skin accessory organ, which has a unique structure and plays important roles in growth and development in mammals [1]. A treatment combination of IGF-1 and EGF altered the growth of isolated HFs in culture and the cyclic regeneration of HFs in Angora rabbits. This growth factor combination regulated the expression of HF growth and development related genes. These findings assist with an understanding of the biological functions of IGF-1 and EGF in HF growth and development and contribute to potential therapies for hair-related diseases in humans, and the improvement of wool production in animals
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