Abstract
Whole cell patch clamp recording from neurones of a slice preparation of the frog optic tectum showed that depolarizing step commands from −70 mV holding potential generated a fast inward current always followed by a fast outward current. The fast outward current was blocked by tetrodotoxin (TTX) or 4-aminopyridine (4-AP), or by replacing external Na + with Li +. When the patch pipette contained Cs + instead of K + the outward current was fully preserved, suggesting that the membrane channels responsible for this response were relatively non-selective in their permeability properties. This current (termed I cat) is a novel example of a non-specific cationic current dependent on influx of Na + and presumably important to control the firing characteristics of these cells.
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