Abstract
The primary goal of this study is to develop a mathematical model that can establish a transfer function relationship between the “external” pulse pressures measured by a tonometer and the “internal” pulse pressure in the artery. The purpose of the model is to accurately estimate and rebuild the internal pulse pressure waveforms using arterial tonometry measurements. To develop and validate a model without human subjects and operators for consistency, this study employs a radial pulse generation system, a robotic tonometry system, and a write model with an artificial skin and vessel. A transfer function model is developed using the results of the pulse testing and the mechanical characterization testing of the skin and vessel. To evaluate the model, the pulse waveforms are first reconstructed for various reference pulses using the model with tonometry data. They are then compared with pulse waveforms acquired by internal measurement (by the built-in pressure sensor in the vessel) the external measurement (the on-skin measurement by the robotic tonometry system). The results show that the model-produced pulse waveforms coinciding well with the internal pulse waveforms with small relative errors, indicating the effectiveness of the model in reproducing the actual pulse pressures inside the vessel.
Highlights
Arterial pulse pressure is an important biomarker for vascular diseases
This section explains the whole process of establishing a transfer function that can accurately predict the blood pressure waveform inside the radial artery from the pulse pressure waveform measured on the skin above the simulator’s wrist by using the robotic tonometry pulse measurement system (RTS)
The current study aims at developing a transfer function model that is capable of reconstructing the internal pulse waveform using the tonometry data
Summary
Arterial pulse pressure is an important biomarker for vascular diseases. In particular, being close to the heart, the pressure in aorta or the central aortic blood pressure (cBP). In order to accurately estimate the cBP waveform from the radial artery AT, it is important to first develop a mathematical model for the relationship between radial intravascular blood pressure waveform and the measured radial pulse pressure by the sensor on the skin surface. The primary goal of this study is to develop a mathematical model that relates the radial pulse pressure measured on the skin surface and the pressure inside the radial artery based on the measurements obtained by a robotic tonometry system To this end, a test set up is created with three main components that include an artificial wrist model (consisting of synthetic skin and blood vessel), a pulse generation system, and a robotic tonometry system. After describing the overall process of establishing the transfer function based on the comparison of the blood pressure waveform measured by built-in pressure sensor in the blood vessel tube and by RTS using a tonometry method, this paper presents the error analysis results between the waveform and the blood pressure waveform measured inside the blood vessel
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have