Abstract
A new chiral bisphosphine, ( S, S)-2,2″-bis[(diethylphosphino)methyl]-1,1″-biferrocene [( S, S)-EtTRAP-H], was synthesized in seven steps in 45% overall yield from ferrocenyloxazoline derived from ( S)-valinol. The new chiral phosphine has only planar chirality, and is able to form a trans-chelate metal complex. ( S, S)-EtTRAP-H is an effective ligand in rhodium-catalyzed asymmetric hydrosilylation of ketones (up to 94% ee). In particular, the hydrosilylation of 2-octanone yielded ( S)-2-octanol with 77% ee.
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