Abstract
A new efficient γ-lactams 4 synthesis was achieved by two successive reactions: alkylation of nitroalkane anions with dimethyl α-(bromomethyl) fumarate 1 leading to the formation of ( E)-1-alkyl-2,3-dimethoxycarbonyl butadienes 3a, b resulting of tandem alkylation–elimination (dehydronitration) processes, followed by an intramolecular cyclization on addition of primary amine.
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