Abstract
Optical coherence tomography (OCT) is a medical imaging modality that is commonly used to diagnose retinal diseases. In recent years, linear and radial scanning patterns have been proposed to acquire three-dimensional OCT data. These patterns show differences in A-scan acquisition density across the generated volumes, and thus differ in their suitability for the diagnosis of retinal diseases. While radial OCT volumes exhibit a higher A-scan sampling rate around the scan center, linear scans contain more information in the peripheral scan areas. In this paper, we propose a method to combine a linearly and radially acquired OCT volume to generate a single compound volume, which merges the advantages of both scanning patterns to increase the information that can be gained from the three-dimensional OCT data. We initially generate 3D point clouds of the linearly and radially acquired OCT volumes and use an Iterative Closest Point (ICP) variant to register both volumes. After registration, the compound volume is created by selectively exploiting linear and radial scanning data, depending on the A-scan density of the individual scans. Fusing regions from both volumes with respect to their local A-scan sampling density, we achieve improved overall anatomical OCT information in a high-resolution compound volume. We demonstrate our method on linear and radial OCT volumes for the visualization and analysis of macular holes and the surrounding anatomical structures.
Highlights
Since its invention in the early 1990s, optical coherence tomography (OCT) has mainly been utilized in ophthalmology [1,2,3], and, with the introduction of spectral domain optical coherence tomography (SD-OCT) in the late 2000s, it has advanced to one of the main diagnostic tools, for diseases affecting the central retina [4,5,6]
A total of 48 radially acquired B-scans with 1024 × 312 pixels were compounded into a volumetric OCT with 1024 × 312 × 1024 pixels
Poor image quality is a challenge in the field of ophthalmology at present
Summary
Since its invention in the early 1990s, optical coherence tomography (OCT) has mainly been utilized in ophthalmology [1,2,3], and, with the introduction of spectral domain optical coherence tomography (SD-OCT) in the late 2000s, it has advanced to one of the main diagnostic tools, for diseases affecting the central retina (macula) [4,5,6]. Due to limitations in high-density B-scan slice acquisition and wavelength, as well as the need for sophisticated reconstruction techniques to improve image quality, linear volumetric OCT has remained the standard for volumetric reconstruction [7]. The OCT systems provide two different modes of scanning patterns. The more commonly used linear pattern consists of contiguous parallel B-scans, as shown in image (A) of Figure 1, whereas the radial scanning pattern is composed of. B-scans, which are acquired with a uniform angular distance around a mutual center point, as shown in image (B) of Figure 1. Acquired B-scans use a scanning protocol with uniform spacing between the parallel B-scan slices. Due to the angular relationship of the
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